Emerging reverse transcriptase inhibitors for HIV-1 infection
نویسندگان
چکیده
منابع مشابه
HIV Nucleoside Reverse Transcriptase Inhibitors
Currently, 16 antiretroviral drugs are approved for treatment of HIV infection. However, even the best currently available regimens pose challenges with regard to adherence, toxicity, antiviral activity, and resistance. New drug development thus confronts the need for improved convenience and tolerability, reduced toxicity, and improved activity against both wild-type and drug-resistant viruses...
متن کاملThe Expanding Class of Non-Nucleoside Reverse Transcriptase Inhibitors for the Treatment of HIV-1 Infection.
alternatives. Because EFV is metabolized by CYP 3A4, other drugs that are inducers or inhibitors of this enzyme may increase or decrease EFV concentrations. Because EFV also induces CYP 3A4, agents that are substrates for this enzyme may have lower concentrations when coadministered with EFV. For example, the concomitant use of the protease inhibitor (PI) atazanavir (Reyataz, ATV, Bristol-Myers...
متن کاملThe Emerging Profile of Cross-Resistance among the Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are widely used to treat HIV-1-infected individuals; indeed most first-line antiretroviral therapies typically include one NNRTI in combination with two nucleoside analogs. In 2008, the next-generation NNRTI etravirine was approved for the treatment of HIV-infected antiretroviral therapy-experienced individuals, including those with prior ...
متن کاملNonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase.
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of the HIV type 1 (HIV-1) reverse transcriptase (RT). Yeast grown in the presence of many of these drugs exhibited dramatically increased association of the p66 and p51 subunits of the HIV-1 RT as reported by a yeast two-hybrid assay. The enhancement required drug binding by RT; introduction of a drug-resistance m...
متن کاملHIV-1 CRF08_BC mutants resistant to reverse transcriptase inhibitors
Human immunodeficiency virus type (HIV)-1 circulating recombinant form 08_BC (CRF08_BC), carrying recombinant reverse transcriptase (RT) gene from subtype B and C, has recently become highly prevalent in Southern China. As the number of patients infected by CRF08_BC increases, it is important to characterize the drug resistance mutations of CRF08_BC, especially against widely used antiretrovira...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Expert Opinion on Emerging Drugs
سال: 2018
ISSN: 1472-8214,1744-7623
DOI: 10.1080/14728214.2018.1474202